Bioinformatics Group

Institute of Molecular Biology NAS RA

Arsen Arakelyan

a_arakelyanArsen Arakelyan, PhD

Head of the Bioinformatics Group
Director of IMB
 +374(10) 282622
Curriculum vitae



Institute of Molecular Biology NAS RA
(2015 – present)

Group Leader
Bioinformatics Group, Institute of Molecular Biology NAS RA
(2011 – present)

Adjunct lecturer (Introduction to Bioscience)
American University of Armenia
(2014 – present)

Head of Bioinformatics Deparment
Russian-Armenian Slavonic University
(2015 – present)

Deputy director
Instiute of Molecular Biology NAS RA

Laboratory of Macromolecular complexes, Institute of Molecular Biology NAS RA


PhD in Molecular and Cellular Biology
Institute of Molecular Biology NAS RA

Master’s degree in Biochemistry
Faculty of Biology, Yerevan State University

Bachelor’s degree in Biochemistry
Faculty of Biology, Yerevan State University

Research interests

High-throughput data analysis
Pathway signal flow analysis
Mining the next generation sequencing data for systems biology research
Telomere bioinformatics

Research grants

Assessment of the impact of genomic and epigenetic alterations on gene expression and biological pathway activation in cancers (PI)
SCS MES RA (15T-1F150), 2015-2017

Analysis of biomolecular pathways involved in complex human diseases (PI)
SCS MES RA (13YR-1F0022), 2013-2015

Multiclass growing support set algorithm for analysis of high-throughput gene expression data (PI)
ANSEF, USA (molbio-3507), 2014

In silico structure-function characterization of Familial Mediterranean fever gene product (pyrin): insights into disease pathogenesis (PI)
SCS MES RA (11B-1f014), 2011-2013

Express test-system for diagnostics of overtraining syndrome (PI)
ME RA & CRDF, USA (CRDF-9070), 2012

Growing support sets for pathway specific microarray gene expression analysis (PI)
ANSEF, USA (NS-molbio-2319), 2011

Selected publications

  1. Arsen Arakelyan , Lilit Nersisyan, David Poghosyan, Lusine Khondkaryan, Anna Hakobyan, Henry Löffler-Wirth, Evie Melanitou, Hans Binder. Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles. PLoS One 2017. 12(11):e0187572.

  2. Nersisyan L, Arakelyan A. A transcriptome and literature guided algorithm for reconstruction of pathways to assess activity of telomere maintenance mechanisms. bioRxiv 200535.  doi:

  3. Arakelyan A, Nersisyan L, Hakobyan A. Application of MATLAB in -Omics and Systems Biology.  Applications from Engineering with MATLAB Concepts, Associate Prof. Jan Valdman (Ed.), ISBN: 978-953-51-2459-7. InTech, Croatia, 2016. DOI: 10.5772/62847.   Full text

  4. Arakelyan A, Nersisyan L, Petrek M, Löffler-Wirth H, Binder H. Cartography of pathway signal perturbations identifies distinct molecular pathomechanisms in malignant and chronic lung diseases. Front. Genet. 2016, 7:79. PubMed  Full text

  5. Nersisyan L, Löffler-Wirth H, Arakelyan A, Binder H. Gene Set- and Pathway- Centered Knowledge Discovery Assigns Transcriptional Activation Patterns in Brain, Blood, and Colon Cancer: A Bioinformatics Perspective. Int. J. of Knowl. Disc. in Bioinf. (IJKDB) 2016, 4(2):46-49. Full text

  6. Hakobyan A, Nersisyan L, Arakelyan A. Quantitative trait association study for mean telomere length in the South Asian Genomes. Bioinformatics 2016, 32(11):1697-700. PubMed   Full text

  7. Hopp L, Nersisyan L, Löffler-Wirth H, Arakelyan A, Binder H. Epigenetic heterogeneity of B-cell lymphoma: Chromatin modifiers. Genes 2015, 6(4):1076-1112. PubMed   Full text

  8. Nersisyan L, Johnson G, Riel-Mehan M et al. PSFC: a Pathway Signal Flow Calculator App for Cytoscape [version 1; referees: 1 approved] F1000Research 2015, 4:480.   PubMed Full text

  9. Nersisyan L, Arakelyan A. Computel: computation of mean telomere length from whole-genome next-generation sequencing data. PLoS One 2015, 10(4):e0125201. PubMed Full text

  10. Binder H, Wirth H, Arakelyan A, Lembcke K, Tiys ES, Ivanisenko VA, Kolchanov NA, Kononikhin A, Popov I, Nikolaev EN, Pastushkova L, Larina IM. Time-course human urine proteomics in space-flight simulation experiments. BMC Genomics 2014, 15 Suppl 12:S2. PubMed Full text

  11. Nersisyan L, Samsonyan R, Arakelyan A. CyKEGGParser: tailoring KEGG pathways to fit into systems biology analysis workflows. Version 2. F1000Res 2014, 3:145. PubMed   Full text

  12. Arakelyan A, Nersisyan L. KEGGParser: parsing and editing KEGG pathway maps in Matlab. Bioinformatics 2013 Feb 15;29(4):518-9. PubMed   Full text

  13. Arakelyan A, Aslanyan L, Boyajyan A. High-throughput Gene Expression Analysis Concepts and Applications. Sequence and Genome Analysis II – Bacteria, Viruses and Metabolic Pathways. ISBN: 978-1-480254-14-5. iConcept Press Ltd, USA , 2013, 71-95. PDF