Bioinformatics Group

Institute of Molecular Biology NAS RA

News&Events

Subscribe to get updates on our news and events.

subscribe

We are now at Science Exchange!

We are happy to announce that we have registered at Science Exchange as a service provider for Bioinformatics data analyses and customized software development. Our team provides data analysis and software development services in a wide variety of fields, including:

  • NGS data analysis
  • Differential gene expression profiling
  • Pathway analysis
  • Computational analysis of telomeres from NGS data
  • Customized software development in Java, R, bash
  • Consulting services

For more, visit our Science Exchange storefront.

 

News: Our first PhD defense!

We are happy to tell that our group’s first PhD product has been released!
The thesis, entitled “Telomere analysis based on high-throughput multi-omics data” by Lilit Nersisyan, supervised by Arsen Arakelyan, was defended in the University of Leipzig on September 1st, 2017. We’d like to thank Hans Binder (IZBI, Uni Leipzig) for his enormous support both in scientific and organizational aspects.

The study was aimed at development and applications of algorithms for analysis of Next Generation Sequencing data to study the biology of telomeres. Our programs for telomere length calculation from DNA sequencing data (Computel) and for analysis of telomere maintenance mechanisms from RNA sequencing datasets have the promise to foster telomere biology research by bringing it to high-throughput systems-biology scale.

Links to the thesis and already published papers:

  1. Thesis: “Telomere analysis based on high-throughput multi-omics data” PDF
  2. Nersisyan L. Integration of Telomere Length Dynamics into Systems Biology Framework: A Review. Gene Regul Syst Bio. 2016, 10:35-42. PubMed  Full text
  3. Hakobyan A, Nersisyan L, Arakelyan A. Quantitative trait association study for mean telomere length in the South Asian Genomes. Bioinformatics 2016, 32(11):1697-700. PubMed   Full text
  4. Nersisyan L, Arakelyan A. Computel: computation of mean telomere length from whole-genome next-generation sequencing data. PLoS One 2015, 10(4):e0125201. PubMed Full text
  5. Nersisyan L, Johnson G, Riel-Mehan M et al. PSFC: a Pathway Signal Flow Calculator App for Cytoscape [version 1; referees: 1 approved] F1000Research 2015, 4:480.   PubMed Full text

Upcoming events

 No upcoming events yet (summer :))

Past events

The BIG Journal Club session #15

It is common to perform gene expression experiments on mice or other model organisms and extrapolate the findings onto humans. How valid is such an extrapolation? We know that gene expression is a dynamic variable that varies not only between different species, but also between tissues and organs in the same individual. It is thus important to distinguish the variations in gene expression across tissues and between species, to reveal the commonalities that reflect evolutionary conservation, and differences that reflect organ’s response to the environment.

Analysis of patterns of gene expression across tissues has been the topic of Ani’s recent capstone with which she graduated from AUA CIS master’s program. On Thursday, we’ll see how this work differs from her diploma work.

Presenter: Ani Sakhlyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 25 May 2017, Thursday (! note the weekday change)

Time: 18:00

Contact: +37494 601703
jc15

The BIG Journal Club session #14

A probably inaccurate estimate of the number of various proteins in a cell is on a scale of 10 000 (20-100). There is an astronomic number of possible interactions between them, however, it is reasonable to believe that the number of actually realized interactions will be less than “astronomical”. Even so, the number of interactions available in the literature is far less than the expected actual number. There are many interaction databases that store such information, which are sometimes inaccurate or incomplete.
The study Ani will talk about on Thursday has had a rather ambitious aim of curating a high-quality human interactome map by literature search and experimental procedures. This study has been conducted in Dana-Farber Cancer Institute, where Ani hopes to do an internship this summer 🙂

Presenter: Ani Khachatryan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 18 May 2017, Thursday (! note the weekday change)

Time: 18:00

Contact: +37494 601703
jc14

The BIG Journal Club session #13

Our genes shape what we can be. The epigenetic states of our genes then shape the current morphology and behavior of differentiated cells. Epigenetics, thus, shapes what we are right now. Is there a way for our cells to remember what we have been before? How do our cells react to the environment? Do the stimuli from the environment cause temporary reactions, or is there a cellular memory associated with those exposures?
During our meeting, we will discuss a paper about latent enhancers: regulators of gene activity and cell state that get activated upon receiving certain signals. They are also the keepers of cellular memory that remember if they have been activated before or not.

Presenter: Maria Nikoghosyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 11 May 2017, Thursday (! note the weekday change)

Time: 18:00

Contact: +37494 601703
jc13

The BIG Journal Club session #12

Technologies move fast. And our perception is that algorithmic support to the data generated by high-throughput sequencing platforms is lagging. It’s possible to obtain information from multiple levels of cell state: the genome, transcriptome and epigenome. The main algorithmic challenge to handle these data is integration of the multi-level information into a sysems biology framework.
In the next meeting we will discuss a paper that has suggested an approach to handle multi-omics data integratively and with the use of signaling networks.

Presenter: Siras Hakobyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 04 May 2017, Thurday (! note the weekday change)

Time: 18:00

Contact: +37494 601703

jc12

The BIG Journal Club session #11

A cure to blindness, Parkinson’s diseases, diabetes and osteoporosis? Having organ transplants grown from the patient’s own cells? Killing less animals in the lab, while having better experimental models for diseases and their treatment? The answer to these questions is tricky to pronounce, but everyone will learn to sooner or later: induced pluripotent stem cells, or iPSCs. Their discovery has led to happy and sad moments in history: from Nobel Prize to a suicide, from hope of curing a series of incurable diseases – to tragic “stem cell therapies” performed in clinics.

Even though the word pluripotent means able to differentiate into any type of cells, their differentiation potential is, in fact, limited: you never know what type of a cell you’ll get, until you observe it differentiating. And this is where bioinformatics may be of help: can we guess the type of iPSCs? What approaches do scientists use for this? On Tuesday we’ll discuss if we have anything to do in this intriguing field.

Presenter: Lilit Nersisyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 25 April 2017, Tuesday

Time: 18:00

Contact: +37494 601703
jc11

The BIG Journal Club session #10

Anna will tell about a study inspired by the ovarian cancer of its author. She not only published a fine paper, but used the study results to choose an unconventional chemotherapy regimen for herself, as gene expression of her tumor suggested a successful immune activation. The chemotherapy was a great choice either due to molecular factors, or a strong placebo effect. Nonetheless, she’s alive and happy.
Now that we’ve got the emotional part set up, the event will be mostly dedicated to the CorEx algorithm used in the study, which was developed by Greg Ver Steeg and Aram Galstyan.

Presenter: Anna Hakobyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 18 April 2017, Tuesday

Time: 18:00

Contact: +37494 601703
jc10

The BIG Journal Club session #8 – Resumed

The 8th Journal Club session will be coming this Tuesday 🙂

Ever wonder why despite the “fantastic” progress in biology, we don’t get new treatments with similar “fantastic” efficiency? Well it takes quite long until a genius idea converts into a newly synthesized drug; and it takes even longer (actually, much, much longer) until that drug reaches the market. What if we take existing drugs that have already passed the painful path of “approvals” and use them for treating other diseases, in other words – repurpose them? That would be awesome! The challenge is – how do you find repurposable drugs and their target diseases?
On Tuesday, Arsen will tell us about computational methods for finding cheap treatments to existing diseases.

Presenter: Arsen Arakelyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 11 April 2017, Tuesday

Time: 18:00

Contact: +37494 601703

jc8

 

The BIG Journal Club session #9

Why do most healthy cells divide only a limited number of times, while cancer cells divide infinitely? Many think that one of the necessary factors is the ability of cancer cells to elongate the ends of their chromosomes – the telomeres. Is it possible to target telomere elongation mechanisms in anti-cancer therapies? Would such therapies stop cancer cells from dividing? This will be discussed during our next meeting. We will also present the computational approach that we have developed in our group to predict the ability of cancer cells to elongate their telomeres.

Presenter: Lilit Nersisyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 04 April 2017, Tuesday

Time: 18:00

Contact: +37494 601703

jc9

 

The BIG Journal Club session #8

Ever wonder why despite the “fantastic” progress in biology, we don’t get new treatments with similar “fantastic” efficiency? Well it takes quite long until a genius idea converts into a newly synthesized drug; and it takes even longer (actually, much, much longer) until that drug reaches the market. What if we take existing drugs that have already passed the painful path of “approvals” and use them for treating other diseases, in other words – repurpose them? That would be awesome! The challenge is – how do you find repurposable drugs and their target diseases?
On Tuesday, Arsen will tell us about computational methods for finding cheap treatments to existing diseases.

Presenter: Arsen Arakelyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 14 March 2017, Tuesday

Time: 18:00

Contact: +37494 601703

jc8

 

The BIG Journal Club session #7

Do you know how sequencing is performed? DNA from many cells is mixed and amplified to rich a signal intense enough to be captured by machines. And suddenly we are talking about single cell sequencing! Is it possible to get a valid signal from an amount of DNA as low as that contained within a single cell? Ashkhen will try to convince us that this “burning” topic of the last years is not a trick, but a serious business 🙂

Presenter: Ashkhen Mkhitaryan (Instigate Design)

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 07 March 2017, Tuesday

Time: 18:00

Contact: +37494 601703

jc7

 

The BIG Journal Club session #6

Anna will talk about her favorite topic: RNAs. This time: circular RNAs! Yet another regulatory level of which we haven’t heard a lot, but which is trending now in the world of  functional genomics.

Presenter: Anna Hakobyan 

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 28 February 2017, Tuesday

Time: 18:00

Contact: +37494 601703

jc6

 

The BIG Journal Club session #5

BIGeeks are presenting: celebrite the Valentine’s day with us!
Anna will talk about Singular value decomposition, principal component analysis and other romantic and cheesy stuff! Candle lights will be provided ^_^

Presenter: Anna Hakobyan 

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 14 February 2017, Tuesday

Time: 18:00

Contact: +37494 601703

jc5

 

 

The BIG Journal Club session #4

Biology is complex: several layers of regulatory interactions exist in each cell that altogether shape who you are right now. And once you think that after twenty years of studying all the existing regulatory layers you may finally be called a scientist, there comes this paper destroying all your previous ambitions. This paper will describe the extra layer of regulation you probably haven’t thought about before: the tRNA level.

Meet us on Tuesday and share the excitement, pain, happiness, whatever  🙂

Francesca Tuorto, Frank Lyko. Genome recoding by tRNA modifications. Open Biology, 2016.   Full text 

Presenter: Maria Nikoghosyan

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 07 February 2017, Tuesday

Time: 18:00

Contact: +37494 601703

JC#4

 

 

The BIG Journal Club session #3

Biologocial pathways have long been there. And scientists (including us :)) have long thought about proper analysis of signal propagation through the pathways. However, no consensus is there yet, and this topic is still open for brainstorming.

On Tuesday, we will discuss the following paper that discusses one way of analyzing signal propagation through pathways:

Sergei Maslov, Kim Sneppen, and I. Ispolatov. Propagation of fluctuations in interaction networks governed by the law of mass action.. arXiv 2006163, 1-17.   Full text 

Presenter: Arsen Arakelyan 

Location: Arrive at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 31 January 2017, Tuesday

Time: 18:00

Contact: +37494 601703

JC#3

 

 

The BIG Journal Club session #2

We will discuss the following paper:

Zhonghui Tang, Oscar Junhong Luo et al. CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell 163, 1-17. PubMed  Full text 

Presenter: Lilit Nersisyan 

Location: Find us at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 24 January 2017, Tuesday

Time: 18:00

Contact: +37494 601703

JC#2

The BIG Journal Club session #1

We will discuss the following paper:

Hadas Keren , Galit Lev-Maor & Gil Ast. Alternative splicing and evolution: diversification, exon definition and function. Nature Reviews Genetics 11, 345–355. PubMed PDF 

Presenter: Anna Hakobyan

Location: Find us at the Institute of Molecular Biology, get on the 3rd Floor, turn left from the elevator, find our sign on one of the doors, enter 🙂

Date: 17 January 2017, Tuesday

Time: 18:00

 

BIGJournalClubs

The BIG Journal Club

We are starting our weekly Journal Club!

We decided to make the journal club sessions public, so that anyone interested in hard-core scientific discussions is welcome to attend.